The APBA2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to APBA2, MINT2, and mXllL. This antibody recognizes Human antigen. The APBA2 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism